https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46767 HIST1H3B/C and H3F3A), altering the epigenetic landscape of primitive oligodendrocyte or astrocyte precursor cells of the pontine region of the brainstem. Lysine‐to‐methionine point mutations at amino acid 27 (H3K27M) co‐occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin‐dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53). This cooperation drives gene expression signatures that inhibit cellular differentiation (ID1/2, Hedgehog) and promotes malignant transformation. Unique to DIPG, is the frequency of co‐occurring sets of genomic insults. However, mapping of the oncogenic signaling pathways activated in response to recurring mutations is unresolved. Herein, known oncogenic signal pathways activated in response to recurring somatic mutations and gene amplifications in DIPG are reviewed. Additionally, an important role for high‐resolution quantitative proteomics/phosphoproteomics in the characterization of signaling cascades are highlighted. These regulate the cell cycle, epigenetics and anti‐apoptotic processes, information critical for the development of improved treatment strategies for DIPG.]]> Wed 30 Nov 2022 11:45:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50443 Wed 26 Jul 2023 08:33:30 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37623 Wed 23 Feb 2022 16:07:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36541 Wed 23 Feb 2022 16:01:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46956 Wed 19 Jul 2023 14:21:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49349 Wed 17 Apr 2024 10:02:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30545 Wed 15 Dec 2021 16:09:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36528 Wed 10 Nov 2021 15:13:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41655 Wed 10 Aug 2022 10:07:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43968 Wed 05 Oct 2022 14:15:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50314 Tue 18 Jul 2023 11:37:22 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43299 Thu 15 Sep 2022 12:58:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36692 Thu 13 Jan 2022 10:31:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37125 Thu 03 Feb 2022 12:20:01 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1006 Sat 24 Mar 2018 08:29:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2404 Sat 24 Mar 2018 08:29:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10935 Sat 24 Mar 2018 08:13:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20019 Sat 24 Mar 2018 07:50:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5181 Sat 24 Mar 2018 07:47:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5289 Sat 24 Mar 2018 07:46:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55064 Mon 08 Apr 2024 12:38:40 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45842 Mon 07 Nov 2022 14:10:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55444 Fri 31 May 2024 11:11:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41096 Fri 22 Jul 2022 18:07:18 AEST ]]>